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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 1
1958 1
1963 1
1965 2
1967 2
1968 5
1969 7
1970 4
1971 14
1972 5
1973 15
1974 7
1975 31
1976 21
1977 29
1978 45
1979 70
1980 88
1981 82
1982 125
1983 150
1984 168
1985 171
1986 200
1987 231
1988 264
1989 471
1990 737
1991 879
1992 1116
1993 1199
1994 1565
1995 1578
1996 1833
1997 1901
1998 2128
1999 2288
2000 2415
2001 2435
2002 2750
2003 2901
2004 3219
2005 3507
2006 4008
2007 4039
2008 4052
2009 4183
2010 4183
2011 4382
2012 4504
2013 4672
2014 4939
2015 4877
2016 4533
2017 4668
2018 4905
2019 4736
2020 5130
2021 5219
2022 4887
2023 4662
2024 1813

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108,645 results

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Page 1
K(+) channel signaling in irradiated tumor cells.
Stegen B, Klumpp L, Misovic M, Edalat L, Eckert M, Klumpp D, Ruth P, Huber SM. Stegen B, et al. Eur Biophys J. 2016 Oct;45(7):585-598. doi: 10.1007/s00249-016-1136-z. Epub 2016 May 10. Eur Biophys J. 2016. PMID: 27165704 Review.
Tumor cells exhibit aberrant expression and activity patterns of K(+) channels. The upregulation of highly "oncogenic" K(+) channels such as the Ca(2+)-activated IK channel may drive the neoplastic transformation, malignant progression, metastasis, or therapy …
Tumor cells exhibit aberrant expression and activity patterns of K(+) channels. The upregulation of highly "oncogenic" K(+) channe …
Recent Developments in Ion Channel and Ion-Related Signaling.
Ohya S. Ohya S. Int J Mol Sci. 2023 Sep 22;24(19):14419. doi: 10.3390/ijms241914419. Int J Mol Sci. 2023. PMID: 37833868 Free PMC article.
Ion channels play an important role in the cellular functions of various organ systems, such as the nervous, cardiovascular, immune, and endocrine systems, and are potential therapeutic targets for treatments of their dysfunctions, via 'channelopathy' [...]....
Ion channels play an important role in the cellular functions of various organ systems, such as the nervous, cardiovascular, immune, …
Calcium Channel Signaling Complexes with Receptors and Channels.
Zamponi GW. Zamponi GW. Curr Mol Pharmacol. 2015;8(1):8-11. doi: 10.2174/1874467208666150507093116. Curr Mol Pharmacol. 2015. PMID: 25966707 Review.
The coupling of GPCRs to calcium channels is optimized through the formation of receptor-channel complexes. ...Coupling efficiency between these two families of channels is also enhanced through the formation of channel-channel complexes. ...
The coupling of GPCRs to calcium channels is optimized through the formation of receptor-channel complexes. ...Coupling effici …
The Inositol Trisphosphate/Calcium Signaling Pathway in Health and Disease.
Berridge MJ. Berridge MJ. Physiol Rev. 2016 Oct;96(4):1261-96. doi: 10.1152/physrev.00006.2016. Physiol Rev. 2016. PMID: 27512009 Free article. Review.
Many cellular functions are regulated by calcium (Ca(2+)) signals that are generated by different signaling pathways. One of these is the inositol 1,4,5-trisphosphate/calcium (InsP3/Ca(2+)) signaling pathway that operates through either primary or modulatory …
Many cellular functions are regulated by calcium (Ca(2+)) signals that are generated by different signaling pathways. One of t …
Emerging Piezo1 signaling in inflammation and atherosclerosis; a potential therapeutic target.
Shinge SAU, Zhang D, Din AU, Yu F, Nie Y. Shinge SAU, et al. Int J Biol Sci. 2022 Jan 1;18(3):923-941. doi: 10.7150/ijbs.63819. eCollection 2022. Int J Biol Sci. 2022. PMID: 35173527 Free PMC article. Review.
To bring the awareness of mechanosensitive Piezo1 role in atherosclerosis and its therapeutic potentials we review recent literature to highlight its involvement in various mechanisms of the disease. Recent Findings: Recent studies reported Piezo1 channel as a sensor, and …
To bring the awareness of mechanosensitive Piezo1 role in atherosclerosis and its therapeutic potentials we review recent literature to high …
Ca(2+) signals in plant immunity.
Köster P, DeFalco TA, Zipfel C. Köster P, et al. EMBO J. 2022 Jun 14;41(12):e110741. doi: 10.15252/embj.2022110741. Epub 2022 May 13. EMBO J. 2022. PMID: 35560235 Free PMC article. Review.
Calcium ions function as a key second messenger ion in eukaryotes. Spatially and temporally defined cytoplasmic Ca(2+) signals are shaped through the concerted activity of ion channels, exchangers, and pumps in response to diverse stimuli; these signals are t …
Calcium ions function as a key second messenger ion in eukaryotes. Spatially and temporally defined cytoplasmic Ca(2+) signals are sh …
More than a pore: ion channel signaling complexes.
Lee A, Fakler B, Kaczmarek LK, Isom LL. Lee A, et al. J Neurosci. 2014 Nov 12;34(46):15159-69. doi: 10.1523/JNEUROSCI.3275-14.2014. J Neurosci. 2014. PMID: 25392484 Free PMC article. Review.
Yet, ion channels often exhibit unexpected properties in vivo because of their interaction with a variety of signaling/scaffolding proteins. Such interactions can influence the function and localization of ion channels, as well as their coupling to intracellu …
Yet, ion channels often exhibit unexpected properties in vivo because of their interaction with a variety of signaling/scaffol …
Calcium channel inactivation: possible role in signal transduction and Ca2+ signaling.
Morad M, Soldatov N. Morad M, et al. Cell Calcium. 2005 Sep-Oct;38(3-4):223-31. doi: 10.1016/j.ceca.2005.06.027. Cell Calcium. 2005. PMID: 16098584 Review.
In the present review we consider the possible role of calcium-dependent inactivation of Cav1.2 in Ca2+ signal transduction and signaling of calcium release from the cardiac sarcoplasmic reticulum. We explore the specific roles of Ca2+-sensing calmodulin-bind …
In the present review we consider the possible role of calcium-dependent inactivation of Cav1.2 in Ca2+ signal transduction an …
Signaling pathways targeting mitochondrial potassium channels.
Rotko D, Kunz WS, Szewczyk A, Kulawiak B. Rotko D, et al. Int J Biochem Cell Biol. 2020 Aug;125:105792. doi: 10.1016/j.biocel.2020.105792. Epub 2020 Jun 20. Int J Biochem Cell Biol. 2020. PMID: 32574707 Free article. Review.
In this review, we describe key signaling pathways regulating potassium channels present in the inner mitochondrial membrane. ...Hence, characterizing the signaling pathways regulating mitochondrial potassium channels will facilitate understanding the …
In this review, we describe key signaling pathways regulating potassium channels present in the inner mitochondrial membrane. …
Addictive drugs modulate GIRK-channel signaling by regulating RGS proteins.
Lomazzi M, Slesinger PA, Lüscher C. Lomazzi M, et al. Trends Pharmacol Sci. 2008 Nov;29(11):544-9. doi: 10.1016/j.tips.2008.07.011. Epub 2008 Sep 12. Trends Pharmacol Sci. 2008. PMID: 18790542 Free PMC article. Review.
Regulator of G-protein signaling (RGS) proteins are strong modulators of G-protein-mediated pathways in the nervous system. One function of RGS proteins is to accelerate the activation-deactivation kinetics of G-protein-coupled inwardly rectifying potassium (GIRK) chann …
Regulator of G-protein signaling (RGS) proteins are strong modulators of G-protein-mediated pathways in the nervous system. One funct …
108,645 results
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